Satellite Meeting: GlycoNeuro

The GlycoNeuro symposium will be held as a post-symposium satellite meeting of Glcyo26. Pre-registration will be required but no additional fee will be charged for registered attendees of Glyco26.

Post-Symposium Satellite Meeting

Date and Time: Friday, September 1, 2023, 18:00-20:00 / Saturday, September 2, 2023, 9:00-18:00
Venue: Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
Registration required, free for local and registered participants of Glyco26. 

Organized by
Kay-Hooi Khoo, Chi-Kuang Yao and Neuroscience Program at Academia Sinica (NPAS)

In 2004, Feb 8-11, the late Professor Robert Yu organized a first ever Glyco-Neurobiology meeting at the Institute of Biological Chemistry, Academia Sinica, Taiwan, as a satellite meeting of the Biennial Meeting of the International and Asian-Pacific Societies for Neurochemistry. Then in 2017, Sept 2-5, 2017, Professor Sandro Sonnino, together with the Korea University and the International and Asian-Pacific Societies for Neurochemistry, organized the 1st International Conference on the Glycobiology of Nervous System in Seoul,  as a post-symposium satellite meeting of Glyco24 held in Jeju Island. Almost 20 years later, the organizer of Glyco26 and the Neuroscience Program of Academia Sinica (NPAS) are pleased to announce that a post-symposium GlycoNeuro satellite meeting will again be held at Academia Sinica, on Sept 1-2, 2023, which will be dedicated to Prof. Robert Yu who passed away in May 18, 2022.

"Dr. Yu had an internationally distinguished career where he made pioneering contributions to our understanding of glycoconjugates, complex sugar molecules that facilitate many biological functions, in health and disease. His research program has identified and structurally characterized about 1/3 of all brain gangliosides, provided important insights into the regulatory mechanisms of ganglioside biosynthesis during development, characterized stage-specific glycoconjugates in neural stem cells, and elucidated immunological properties of glycosphingolipids and how their dysregulation contributes to multiple neurological disorders, including Guillain-Barre Syndrome, multiple sclerosis, Alzheimer’s disease, and Parkinson’s disease as well as to cholera and cancer." -- taken from the Obituary published in Augusta Chronicle

The GlycoNeuro satellite meeting will address all aspects related to the roles of glycoconjugates in the nervous system, particularly in neurodegenerative diseases. Recent technical developments have highlighted the importance of maintaining a properly checked-and-balanced interactions between the glial cells and neurons. This meeting aims to bring together neuroscientists and glycoscientists to focus on how gangliosides, polysialic acids and a host of other glycoconjugates mediate and impact the interactive network of the central nervous system, with and without engaging an equally diverse range of glycan binding proteins including the siglecs. Other than two Keynote lectures and several invited talks, short oral presentations will be selected from Abstracts submitted for Poster presentation. 
Sept 1, 2023
From 17:20, Social Mixing (light snack and drinks provided)

18:00 – 19:30
Opening Session, introduced by Kay-Hooi Khoo (IBC, Academia Sinica, Taiwan)
Sandro Sonnino (U Milan, Italy)
Opening and Introductory Lecture: "The glycans of glycoconjugates in neuronal processes"
Rita Gerardy-Schahn (Hannover Medical School, Germany)
Glyco-Neuroscience Perspective Lecture: "Chemistry and biology of polysialic acid with focus on neurobiological aspects"
Introducing Speakers and local NPAS scientists

Sept 2, 2023

09:00 - 10:40
Scientific Session I, Invited Talks (4x 20+3 min),
chaired by Chih-Cheng Chen (IBMS, Academia Sinica, Taiwan)
Matt Macauley (U Alberta, Canada)
"Studying the in vivo role of CD33 isoforms in an Alzheimer's disease mouse model"
Kenji Uchimura (U Lille, France)
"Sulfated glycans that regulate microglial function"
Jian-Jing Siew (IBMS, Taiwan)
"Microglial galectin-3 aggravates tauopathy"
Takashi Angata (IBC, Academia Sinica, Taiwan)
"Deciphering the molecular basis and functional roles of glycan-based immune checkpoints in neurodegenerative diseases"
10:40 - 11:00
Coffee Break

11:00 – 11:30
Short Talks from Posters (2x 12+2 min),
chaired by Takashi Angata (Academia Sinica, Taiwan)
Hua-Chien Chang (IBC, Academia Sinica, Taiwan)
"Identification and mapping of novel sulfated glycotopes expressed on mouse brains and isolated neurons by mass spectrometry-based sulfoglycomic analysis"
Yan-Hua Lee (IBMS, Academia Sinica, Taiwan)
"Siglecs Alteration in Huntington’s Disease"
11:30 - 12:10
Keynote Lecture I, chaired by Yijuang Chern (IBMS, Academia Sinica, Taiwan)
"Siglecs Alteration in Huntington’s Disease"
Herbert Hildebrandt (Hannover Medical School)
"Modulation of microglia and macrophage activity by polysialic acid and its Siglec receptors"
12:10 – 13:20
Lunch Break and Poster viewing

13:20 - 14:00
Keynote Lecture II, chaired by Chi-Hon Lee (ICOB, Academia Sinica, Taiwan)
Alexey Pshezhetsky (U Montreal, Canada)
" Mucopolysaccharidosis and Epileptic encephalopathy, the two extremes of aberrant heparan sulfate regulation in the CNS"
14:00 - 15:40
Scientific Session II, Invited Talks (4x 20+3 min),
chaired by Kay-Hooi Khoo (IBC, Academia Sinica, Taiwan)
Sophia Shi (Stanford U, USA)
"Cerebrovascular glycocalyx degeneration in aging and neurodegenerative disease"
Yun-Ru (Ruby) Chen (GRC, Academia Sinica, Taiwan)
"Investigation of abnormal glycosylation in Alzheimer's disease"
Cheng-Ting Chien (IMB, Academia Sinica, Taiwan)
"Glycosylation in dendrite development and degeneration"
Chihiro Sato (Nagoya U, Japan)
"Comparative study of the polysialic acid synthesized by ST8SIA2 and ST8SIA4"
15:40 - 16:00
Coffee Break

16:00 - 16:45
Short Talks from Posters (3x 12+2 min),
chaired by Chi-Kuang Yao (IBC, Academia Sinica, Taiwan)
Masaya Hane (Nagoya U, Japan)
A new analytical method measuring the interaction between polysialic acid and dopamine-lead compounds"
Keisuke Komatsuya (Tokyo Metropolitan Institute of Medical Science, Japan)
“Signal Transduction of GPI-anchored NB-3 in Ganglioside GD1b Lipid Rafts of Cerebellar Granule Cells”
Giulia Lunghi (U Milan, Italy)
“The neuroprotective role of the oligosaccharide of ganglioside GM1 in Parkinson’s disease”
16:45 - 17:45
Poster Session
Closing Discussion

** Please refer to "Speakers/Satellite Meetings" for more speakers' information**