Title: Mucin Glycans in the Regulation of Microbial Virulence
Professor Ribbeck obtained her Bachelor’s degree and her Ph.D. in Biology from the University of Heidelberg, Germany. She continued her postdoctoral research at the European Molecular Biology Laboratory, Heidelberg, Germany, and the Department of Systems Biology, Harvard Medical School. Professor Ribbeck established her independent research group as a Bauer Fellow at the FAS Center for Systems Biology, Harvard University, in 2007 and joined the Department of Biological Engineering at MIT as an Assistant Professor in 2010.
Her laboratory studies the basic mechanisms of biological hydrogels by which mucus barriers exclude, or allow passage of different molecules and pathogens, and the mechanisms pathogens have evolved to penetrate mucus barriers. It hopes to provide the foundation for a theoretical framework that captures general principles governing selectivity in mucus, and likely other biological hydrogels such as the extracellular matrix, and bacterial biofilms. Her Lab’s work may also be the basis for the reconstitution of synthetic gels that mimic the basic selective properties of biological gels.
Title: Targeting Human Viruses with Broadly Protective Low-Sugar Vaccines
Professor Wong received his B.S. and M.S. degrees from National Taiwan University, and Ph.D. (1982) in Chemistry from MIT. He then worked at Harvard University as a postdoctoral fellow, became an assistant professor at Texas A&M University in 1983, and became a professor in 1987. He was Professor and Ernest W. Hahn Chair in Chemistry at the Scripps Research Institute (1989–2006), Director of Genomics Research Center (2003–2006), and President of Academia Sinica (2006-2016). He is currently the Scripps Family Chair Professor of Chemistry at The Scripps Research Institute with a joint appointment at Genomics Research Center, Academia Sinica.
Professor Wong receives numerous awards, including the U.S. Presidential Green Chemistry Challenge Award, the ACS Claude Hudson Award in Carbohydrate Chemistry, Creative Work in Synthetic Organic Chemistry, and the Cope Medal, the Wolf Prize in Chemistry. He is a member of Academia Sinica, the American Academy of Arts and Sciences, and the U.S. National Academy of Sciences.
His research interests are in the field of chemical biology and synthetic chemistry, including the synthesis of complex carbohydrates and glycoproteins associated with disease progression. He is the author of over 700 publications (H-index 144) and 100 patents.
Title: Exploring Glycosylation-dependent Pathways as Modulators of Intestinal Inflammation
Dr. Mariño received her Ph.D. in Chemistry from the University of Buenos Aires. She continued her training as a postdoc at the University of Dundee (Scotland, UK) and later, at the National Institute for Bioprocessing, Research, and Training (Dublin, Ireland), integrating her chemical vision of carbohydrates into the biochemistry of glycans and the structural analysis of glycoconjugates in physiological and pathological contexts. After relocating to Argentina, she established the Functional and Molecular Glycomics Lab (Institute of Biology and Experimental Medicine). As an Independent Researcher at CONICET, she focuses on how inflammatory conditions could alter the glycome in inflammatory bowel diseases and colorectal cancer and whether these changes can promote the establishment of altered lectin-glycan interactions and, in doing so, influence the immune response. Her goal is to capitalize on glycoimmunological mechanisms that could potentially re-wire immune circuits in these pathologies, providing novel opportunities for translational medicine.
Based on her glycoanalytical experience, she also offers consultancies on glycosylation analysis to the Latin American Life Sciences Industry. She received several prizes for her work, including the "Carlos B. Udaondo" award from the National Academy of Medicine (2019). She is the current National Representative for Argentina at the International Glycoconjugate Organization.
The research activity of Professor De Castro is in carbohydrate structural chemistry, and her training in this subject started during her bachelor thesis, which focused on plant polysaccharides. Since then, even though Professor De Castro continued her work on carbohydrate structural chemistry, she shifted her interests and dedicated her activity to the analysis of the bacterial membrane carbohydrate components, paying attention, but not limiting the work, to Gram-negative bacteria and lipopolysaccharides (LPSs). This work has resulted in the development of state-of-the-art chemical and spectroscopical approaches that have been later applied with success to different kinds of carbohydrates, such as those from the bacteria of the gut microbiota or those from the giant viruses. This last topic is Professor De Castro's major field of research.
Professor De Castro is the author/co-author of about 130 peer-reviewed publications, an associated Editor for the journal Carbohydrate Polymers, and a member of the editorial board of Carbohydrate Research, Glycobiology, and Polysaccharides. She fruitfully collaborates with different research institutions, such as the Department of Plant Pathology (University of Nebraska Lincoln, NE, USA) and the Structural and Genomics Information Laboratory in Marseille (France).
Title: Rethinking the Paradigm: New Roles for Non-Coding RNA in Controlling the Cancer Glycome.
Dr. Lara K. Mahal is the Canada Excellence Research Chair in Glycomics and a Professor of Chemistry at the University of Alberta. Her work focuses on systems-based approaches to understanding glycans, complex sugars that encode information governing human health. She developed lectin microarray technology, a high-throughput method for analyzing glycans that is now widely applied to understand the role of these sugars in a multitude of systems, from clinical cancer research to host-pathogen interactions. She is also known for her ground-breaking work on microRNA regulation, including the discovery of upregulation as a common feature of the miRNA regulatory landscape. She is the recipient of numerous awards, including the Beckman Foundation Fellowship (2004), NSF CAREER Award (2007), Sloan Foundation Fellowship (2008), NIH Director’s New Innovator Award (2008), the Horace S. Isbell Award (2017) and the Canada Excellence Research Chair in Glycomics (2019). In 2022, she founded the Glycomics Institute of Alberta (GIA) at the University of Alberta.
Title: Genome-wide Analysis of Heparan Sulfate Assembly
Dr. Ryan Weiss began his diverse scientific training by earning his B.S. in Chemistry in 2008 at Point Loma Nazarene University in San Diego, CA, USA. He then received his Ph.D. in Chemistry in 2015 at the University of California, San Diego, under the supervision of Prof. Yitzhak Tor, where he studied the design, synthesis, and application of small molecule antagonists of heparin- and heparan sulfate-protein interactions. As an NIH K12 postdoctoral fellow in Prof. Jeffrey Esko’s group at the Department of Cellular and Molecular Medicine at the University of California, San Diego, his research focused on utilizing whole-genome screening methods to investigate the regulation of heparan sulfate biosynthesis. Dr. Weiss began his independent career as an assistant professor at the Complex Carbohydrate Research Center at the University of Georgia in January 2021. Research in the Weiss Laboratory focuses on studying the structure, function, and regulation of complex carbohydrates in human biology and disease. In addition, his lab is dedicated to developing pharmacological and cell-based tools to aid in the discovery of novel targets and approaches for modulating glycan assembly in relevant human disorders.
Dr. Linda Hsieh-Wilson is a Professor of Chemistry at the California Institute of Technology. She was born in New York City and obtained her B.S. degree magna cum laude in chemistry from Yale University in 1990. In 1996, she received her Ph.D. in chemistry from the University of California at Berkeley, where she was a National Science Foundation predoctoral fellow in the laboratory of Professor Peter Schultz. In 1996, she moved to Rockefeller University to study neurobiology with Professor and Nobel Laureate Paul Greengard as a Damon Runyon-Walter Winchell postdoctoral fellow. Hsieh-Wilson joined the faculty at the California Institute of Technology in 2000, where she became an associate professor of chemistry in 2006 and a full professor in 2010. She was an Investigator at the Howard Hughes Medical Institute from 2005-2014, and in 2015, she was elected to the American Academy of Arts and Sciences.
Professor Hsieh-Wilson has pioneered the application of organic chemistry to understand the roles of carbohydrates and protein glycosylation in neurobiology. Her honors include a Beckman Young Investigator Award (2000), Research Corporation Research Innovation Award (2000), Alfred P. Sloan Fellowship (2003), Eli Lilly Award in Biological Chemistry (2006), Arthur C. Cope Scholar Award (2008), Gill Young Investigator Award in Neuroscience (2009), and Horace S. Isbell Award in Carbohydrate Chemistry (2014).
Professor Yasuhiro Kajihara received his Ph.D. from the Tokyo Institute of Technology in 1993. He spent two years at the Life Science Research Laboratory of Japan Tobacco Inc. as a postdoctoral fellow. In 1995 he joined Yokohama City University as an assistant professor and was then promoted to associate professor in 2001 and full professor in 2007. At YCU, he developed synthetic methods for oligosaccharides and glycoproteins. In 2009, he moved to the Department of Chemistry at Osaka University. He studies new synthetic methods of glycoproteins in order to understand how oligosaccharides regulate protein functions.
Title: Targeting Cancer-Associated Sialylation for Cancer Immunotherapy
Dr. Heinz Läubli received his M.D. and Ph.D. at the Institute of Physiology, University of Zürich (Switzerland). He is now an Assistant Professor and a Research group leader at the University of Basel and an Attending physician in the Division of Oncology, and Head of Glycobiology Research in the Department of Biomedicine, at the University Hospital Basel. Dr. Heinz’s research interests are to improve immunotherapy for cancer patients by using translational in vitro and in vivo tumor models, performing correlative analysis of patients treated with immunotherapy, and conducting early clinical interventional trials. His group has been studying the interaction between siaologlycans and their interaction with Siglec receptors on immune cells. It has demonstrated that this pathway can be targeted to augment T-cell stimulation and tumor control. His research goals also include the improvement of cancer immunotherapy by modifying glycans in the tumor microenvironment and glycans of cellular products for adoptive cell therapies, including genetically modified T cells.
Professor Tadashi Suzuki received his Ph.D. (1997) from Department of Biochemistry and Biophysics at University of Tokyo, Japan. He demonstrated the activity and characterized the enzymatic properties of the cytoplasmic peptide:N-glycanase (PNGase/Ngly1) mammalian cells and proposed that this enzyme may be involved in the quality control of newly synthesized glycoproteins. Dr. Suzuki was a postdoctoral fellow at Department of Biochemistry and Cell Biology, State University of New York at Stony Brook (1997-2000). He was an Assistant Professor at University of Tokyo (2002-2004) and a Visiting Associate Professor at Osaka University Graduate School of Medicine (2004-2007). During this period, he identified two cytoplasmic glycosidases, endo-beta-N-acetylglucosaminidase (ENGase) and alpha-mannosidase (Man2C1), involved in the catabolism of free glycans released by the cytoplasmic PNGase. He was a Team Leader at Glycometabolome Team, Systems Glycobiology Research Group, RIKEN. He currently serves as a Chief Scientist at Glycometabolic Biochemistry Laboratory, RIKEN Cluster for Pioneering Research.
His current research interests are (1) clarification of the novel catabolic pathway for glycans on glycoproteins; (2) characterization of biological functions of cytoplasmic peptide:N-glycanase (Ngly1) for the non-lysosomal catabolic pathway of N-glycans; (3) development of new analytical methods for glycans; and (4) development of therapeutics for NGLY1-deficiency.
@TAIPEI, AUG 27~SEP 1 2023
Meet our invited speakers for the Glyco26. To learn more about each individual speaker, please click on the photos below. Speakers are arranged by the first alphabet of surname but starting from a randomized alphabet each time.
Title: Labeling, Imaging and Proteomics of Brain Glycans
Dr. Xing Chen is currently a Changjiang Distinguished Professor and Dean of the College of Chemistry and Molecular Engineering at Peking University. He completed his bachelor’s degree in chemistry in 2002 from Tsinghua University and his Ph.D. in chemistry in 2007 from University of California, Berkeley, under Prof. Carolyn Bertozzi and Prof. Alex Zettl. He then joined the laboratory of Prof. Timothy Springer at Harvard Medical School as an LSRF postdoctoral fellow, where his research focused on structural immunology. Dr. Chen started as an Assistant Professor of Chemistry at Peking University in 2010 and was promoted directly to Full Professor with tenure in 2016. He is also affiliated with Center for Life Science (CLS) and Synthetic and Functional Biomolecule Center (SFBC) of Peking University. Some of his recent awards include ACS Horace S. Isbell Award (2021), Xplore Prize (2010), Tan Kah Kee Young Scientist Award (2020), Okeanos-CAPA Senior Investigator Award at the Chemical and Biology Interface (2019), CCS-RSC Young Chemist Award (2018), ACS David Y. Gin New Investigator Award (2016), IGO Young Glycoscientist Award (2015), and National Science Fund for Distinguished Young Scholars (2014). His current research interest focuses on chemical glycobiology.