Nagoya University Graduate School of Medicine, Japan
Title: Crosstalk of glycosaminoglycans and cell surface receptors in neural wiring/rewiring
Dr. Kadomatsu started his career in basic medical research after being a physician of pediatric neuroblastoma. During his graduate studies, he discovered the glycan-binding growth factor midkine. He has been researching the involvement of cancer, neurology, and inflammation. For this achievement, he received the Young Investigator Award from the Japanese Biochemical Society in 1997.
His research with a Chinese graduate student led him to become particularly interested in the relationship between glycans and the nervous system, which has become the focus of his research. He was a representative of "Neuroglycobiology" (2011-2015), the Grant-in-Aid for Scientific Research on Innovative Areas by the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT). He currently represents the "Human Glycome Project," Roadmap 2020, MEXT.
He served as the President of the Japanese Society of Carbohydrate Research, Editor-in-Chief of the Journal of Biochemistry, and representative of the Asia/Australia/Africa region of the Advance in Neuroblastoma Research Association. He holds an honorary professorship from the Chinese University of Hong Kong.
Title: Glycan: A Target for Diagnosis and Treatment of Brain Tumors
Professor Atit Silsirivanit received his Ph.D. in Medical Biochemistry from Khon Kaen University in 2011. During 2014-2016, he was supported by the Japan Society for the Promotion of Science (JSPS) to pursue postdoctoral training at the Department of Tumor Genetics and Biology, Kumamoto University, Japan. His current position is as an Associate Professor of Biochemistry at the Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Thailand. His research focuses on the involvement of glycans and glycosylation in the development and progression of cancers, including cholangiocarcinoma, glioblastoma, meningioma, and melanoma. We are currently working on 1) The role of glycans and glycosylation in cancer, 2) Identification of glycobiomarkers for cancer diagnosis, monitoring, and prognostic prediction, and 3) Application of lectins for detection of glycobiomarkers.
University of Natural Resources and Life Sciences (BOKU), Austria
Title: Glycans in Host-Pathogen Interactions
Dr. Katharina Paschinger gained her doctorate in 2008 and has been a self-financed FWF Fellow at the Universität für Bodenkultur Wien since 2009. She has led three projects related to glycan diversity in different species, ranging from model and parasitic nematodes to marine species, such as molluscs and echinoderms. Over the years, she has developed and optimized glycomic workflows based on off-line HPLC-MALDI-TOF MS, suitable for discovering a wide range of glycan epitopes, including unusual fucosylated, glucuronylated, sulphated, and zwitterionic modifications of N-glycans, with roles in self/non-self-recognition. She is the author of some 50 original papers, including publications in Molecular & Cellular Proteomics and Nature Communications, as well as various review articles and book chapters. Privately, she is a mother of three children and a passionate gardener and opera lover.
Professor Yasuhiro Kajihara received his Ph.D. from the Tokyo Institute of Technology in 1993. He spent two years at the Life Science Research Laboratory of Japan Tobacco Inc. as a postdoctoral fellow. In 1995 he joined Yokohama City University as an assistant professor and was then promoted to associate professor in 2001 and full professor in 2007. At YCU, he developed synthetic methods for oligosaccharides and glycoproteins. In 2009, he moved to the Department of Chemistry at Osaka University. He studies new synthetic methods of glycoproteins in order to understand how oligosaccharides regulate protein functions.
Title: Altered Glycosylation in Cancer Affects Cellular Receptor Tyrosine Kinases and Regulates Cancer Cell Sensitivity to Therapeutic Drugs.
Celso A Reis is the Head of the Glycobiology in Cancer group at i3S-Institute for Research and Innovation in Health, University of Porto, Portugal. He serves as a member of the Board of Directors of i3S and on the Board of IGO. He is a Professor at the Institute of Biomedical Sciences, University of Porto, and an invited Professor at the Faculty of Medicine of the University of Porto. Celso A Reis has published 227 peer-reviewed papers with over 15400 citations and with an H-index of 56 (Scopus). He is the author of several book chapters and patents. Currently, he leads an international multidisciplinary team working on glycobiology in human diseases focusing on cancer. His lab investigates the molecular mechanisms controlling glycosylation in cancer and the role of glycans during carcinogenesis and tumor progression. He has made several contributions to the development of novel strategies to improve cancer diagnosis, prognosis, and patient stratification. These include the studies on the role of glycosyltransferases regulating the biosynthesis of several glycans involved in cancer, such as those controlling critical steps on mucin-type O-glycosylation and N-glycosylation, with impact in cancer invasion and metastasis, as well as the tumor microenvironment.
Title: A Sugar Coat on Neuronal Surface: The Supramolecular Assembly of Glycosaminoglycans and Glycoproteins in Regulating Neuroplasticity
Dr. Jessica Kwok is an Associate Professor in Neuroscience at the University of Leeds. Her lab focuses on elucidating the functions of a pericellular coat called perineuronal net, with the main components being glycosaminoglycans (GAGs) and glycoproteins, in the regulation of neuroplasticity. The role of the GAGs in plasticity and axon regeneration has been the main research topic. In the last ten years, her work has played the key role in establishing the mechanism of PNN formation, the interaction of different PNN molecules, and how the interactions define the PNN structure and exert their effects on plasticity. The work has led to the current widely accepted concept that PNNs are crucial in controlling central nervous system (CNS) plasticity. These concepts allow her to design plasticity enhancement treatment for repairing and recovering deficits in the CNS, with a focus on spinal cord injury and memory enhancement.
Title: Cell-based Mucin Array for Discovery and Characterization of Mucinase and Glycan-Binding Modules.
Dr. Narimatsu is an Associate Professor at Copenhagen Center for Glycomics, Ph.D. (2008, Tsukuba University, Japan). His study focuses on the structure, biosynthesis, and genetic regulation of complex carbohydrates. He received training for eight years at the glycobiology lab, Research Center for Medical Glycoscience (RCMG) in Japan. Joined a Center of Excellence in Glycomics funded by the Danish National Research Foundation at the University of Copenhagen in 2012 and contributed to developing a comprehensive and high-throughput platform for CRISPR/Cas9 gene targeting of the human glycome (GlycoCRISPR), a large library of glycoengineered cells (GlycoDisplay), a cell-based platform for the display and production of human Mucin tandem repeat (MucinDisplay). His research interests include a basic understanding of genetic regulation and biosynthesis of protein glycosylation, consequences of deficiencies in glycosylation in diseases, and biomedical applications.
His group has taken a global "glycogenome" engineering approach to protein glycosylation and proposed a Cell-Based glycan array platform to display the human glycome–i.e., display of all human glycans on proteins, proteoglycans, and lipids. This self-renewable array is useful for discovering biological interactions involving glycans, and screening of true high-affinity interactions with glycans requires the natural biological context of specific proteins and cell surfaces.
Title: Sulfated glycosaminoglycans - Studies in diversity
Dr. Kitagawa received his Ph.D. in Biochemistry in 1991 from Kyoto University. He did his doctoral work in the laboratories of Prof. Ikuo Yamashina and Prof. Toshisuke Kawasaki on the purification and characterization of cancer-associated carbohydrate antigens by using monoclonal antibodies raised against human cancer cells. Dr. Kitagawa went on to do postdoctoral work with Dr. James C. Paulson at Cytel Corporation and Scripps Research Institute. In Dr. Paulson’s laboratory, he worked on the molecular cloning and characterization of several sialyltransferases. In 1994 he obtained an assistant professor position at the Department of Biochemistry, Kobe Pharmaceutical University, where he started to work on the structure and biosynthesis of sulfated glycosaminoglycans. He was promoted to associate professor in 2000 and full professor in 2005. He received the young scientist award of the Japanese Society of Carbohydrate Research in 1999, the PSJ (Pharmaceutical Society of Japan) award for young scientists in 2001, the young investigator award of the Japanese Biochemical Society in 2002, and the PSJ award for Divisional Scientific Promotions in 2013. He has continued to work on the functions and the control of the biosynthesis and degradation of sulfated glycosaminoglycans to clarify the causes of various disorders.
Dr. Vered Padler-Karavani received her PhD in biochemistry from Tel Aviv University. She then did her postdoctoral training with Prof. Ajit Varki at The University of California, San Diego (UCSD) and subsequently established The Laboratory for Glycoimmunology at Tel Aviv University The George S. Wise Faculty of Life Sciences, Department of Cell Research and Immunology, The Shmunis School of Biomedicine and Cancer Research. Her research combines glycobiology, immunology, bio-nanotechnology, cancer research and xenotransplantation, and involves cutting edge technologies within these disciplines. She received several prestigious grants from the European Commission (Marie Curie, Health Consortium, ERC) to investigate various aspects of immunology of carbohydrates. With TRANSLINK health consortium (6 academic institutes, 5 hospitals and 3 companies from Israel, Italy, France, Spain, UK, Sweden, Canada and USA; https://cordis.europa.eu/project/id/603049), she investigated risk factors of animal-derived heart valve implants, in ~5,000 patients. Her research is currently focused on studying mechanisms of glycan immune recognition and responses in animal models and in humans, in vitro and in vivo. Particularly, the immunological basis of anti-carbohydrate antibodies and their implications on cancer and heart diseases, and on developing novel diagnostics and therapeutics for such diseases.
Title: Quantitative descriptions of structure-function relationships of glycoSHIELD of coronavirus spike proteins
Dr. Danny Hsu is a Research Fellow at the Institute of Biological Chemistry, Academia Sinica. During his doctorate study at Utrecht University, the Netherlands, he determined the atomic structure of a lantibiotic, nisin, in complex with Gram-positive bacterial cell wall precursor, Lipid II. He coined the term "pyrophosphate case" to explain how nisin targets Lipid II to achieve its antimicrobial activity, providing a blueprint for future antibiotics developments. During his postdoctoral research at the University of Cambridge, UK, Danny demonstrated the proof of concept of using solution-state NMR spectroscopy to investigate the co-translational folding of nascent polypeptide chains on the ribosome. His earlier independent research focused on the folding mechanisms and functional implications of topologically knotted proteins. He currently focuses on developing an integrated biophysics and structural biology platform, including cryo-electron microscopy, mass spectrometry, and molecular modeling, to investigate the structure-activity relationship (SAR) of glycoproteins, and coronavirus spike proteins, in particular, and how mutations impact on the SAR in the context of glycosylation.
@TAIPEI, AUG 27~SEP 1 2023
Meet our invited speakers for the Glyco26. To learn more about each individual speaker, please click on the photos below. Speakers are arranged by the first alphabet of surname but starting from a randomized alphabet each time.